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Updated: May 24, 2026
Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
Published on: May 17, 2019
Low expression of RECK indicates a shorter survival for patients with invasive breast cancer
Yue Zhang1, Shaoqiang Cheng, Guoqiang Zhang
1Department of Medical Oncology, The Third Affiliated Hospital of Harbin Medical University, Harbin, China.
Abstract:
Expression cloning was used to initially isolate the reversion-inducing cysteine-rich protein with Kazal motifs (RECK) gene as a suppressor of transformation. The gene was found to encode a membrane-anchored regulator of MMPs. Experimental studies showed that RECK can suppress tumor invasion, metastasis, and angiogenesis. However, the clinical impact of RECK remains unclear. To assess the clinical significance of RECK expression in invasive breast cancer, a total of 119 patients with invasive breast cancer were retrospectively examined. Expression of RECK in tumor tissues was assessed by immunohistochemical staining. A significant correlation between RECK expression and 5-year survival rate was documented. The 5-year survival rate for patients with strong RECK expression was significantly higher than that for patients with weakly expressing tumors. Univariate and multivariate analyses confirmed that reduced RECK expression was an independent and significant factor in predicting a poor prognosis. In conclusion, RECK expression is a significant prognostic factor correlated with long-term survival for patients with invasive breast cancer. RECK expression is therefore a potentially useful prognostic marker for breast cancer.
Insights
Reversion-inducing cysteine-rich protein with Kazal motifs (RECK) expression is a significant prognostic factor in invasive breast cancer. High RECK expression correlates with a better 5-year survival rate, indicating its potential as a breast cancer marker.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- The reversion-inducing cysteine-rich protein with Kazal motifs (RECK) gene was initially identified as a suppressor of transformation.
- RECK encodes a membrane-anchored regulator of matrix metalloproteinases (MMPs), known to influence tumor invasion, metastasis, and angiogenesis.
Purpose of the Study:
- To investigate the clinical significance of RECK gene expression in patients with invasive breast cancer.
- To determine if RECK expression levels correlate with patient prognosis and survival rates.
Main Methods:
- Retrospective analysis of 119 patients with invasive breast cancer.
- Immunohistochemical staining of tumor tissues to assess RECK expression levels.
- Univariate and multivariate analyses to evaluate prognostic factors.
Main Results:
- A significant positive correlation was found between strong RECK expression and a higher 5-year survival rate.
- Reduced RECK expression was identified as an independent predictor of a poor prognosis in invasive breast cancer.
- RECK expression levels significantly impacted long-term patient survival.
Conclusions:
- RECK expression is a significant prognostic factor for long-term survival in invasive breast cancer patients.
- Assessing RECK expression in tumors may serve as a valuable prognostic marker for breast cancer.
- Further research could explore therapeutic strategies targeting RECK in breast cancer treatment.
