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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying DNA...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...

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Related Experiment Video

Updated: May 24, 2026

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
09:42

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images

Published on: September 7, 2017

Programming of DNA methylation patterns.

Howard Cedar1, Yehudit Bergman

  • 1Department of Developmental Biology and Cancer Research, Hebrew University Medical School, Ein Kerem, Jerusalem, Israel. cedar@cc.huji.ac.il

Annual Review of Biochemistry
|March 13, 2012
PubMed
Summary
This summary is machine-generated.

DNA methylation is a key epigenetic mark that regulates gene expression and is crucial for development. Aberrant DNA methylation is linked to diseases, aging, and environmental factors.

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DNA Methylation: Bisulphite Modification and Analysis

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Related Experiment Videos

Last Updated: May 24, 2026

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
09:42

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images

Published on: September 7, 2017

Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution
13:47

Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution

Published on: February 24, 2015

DNA Methylation: Bisulphite Modification and Analysis
12:34

DNA Methylation: Bisulphite Modification and Analysis

Published on: October 21, 2011

Area of Science:

  • Epigenetics
  • Molecular Biology
  • Genomics

Background:

  • DNA methylation is a critical epigenetic mechanism for gene regulation.
  • It acts as a maintainable mark to establish silent chromatin after DNA replication.
  • Germline DNA methylation undergoes dynamic erasure and re-establishment during early mammalian development.

Purpose of the Study:

  • To elucidate the role of DNA methylation in genome annotation and gene repression.
  • To describe the dynamic patterns of DNA methylation during embryonic development.
  • To highlight the significance of DNA methylation in cell-type specification and disease.

Main Methods:

  • The study is based on a review of existing literature and established knowledge in the field of epigenetics.
  • Analysis of DNA methylation patterns during key developmental stages.
  • Correlation of methylation changes with gene expression and cellular differentiation.

Main Results:

  • DNA methylation patterns are established during implantation, leading to global gene repression with protection of CpG islands.
  • Postimplantation development involves stage- and tissue-specific methylation changes that define cell identity.
  • Aberrant DNA methylation is implicated in various diseases, including cancer and fragile X syndrome, and is influenced by aging and environment.

Conclusions:

  • DNA methylation is a fundamental epigenetic regulator essential for normal development and cellular identity.
  • Dysregulation of DNA methylation has profound implications for health and disease.
  • Understanding DNA methylation dynamics is crucial for advancing epigenetic research and therapeutic strategies.