Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of plasma pTau181 levels on clinician diagnostic confidence and management in memory and cognition clinics: A multi-site before-and-after study.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026
Same author

Self-Reported Driving Behaviours and the Relationship With Sleepiness in Subjective Cognitive Decline and Mild Cognitive Impairment.

Journal of geriatric psychiatry and neurology·2026
Same author

Randomized, double-blind study of zervimesine in mild to moderate Alzheimer's disease.

Journal of Alzheimer's disease : JAD·2026
Same author

Data-driven Mori-Zwanzig modeling of Lagrangian particle dynamics in turbulent flows.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Consumer perspective on breast density notification in Australia.

Ecancermedicalscience·2026
Same author

Design and implementation of an AAPM volunteer database for advancing global medical physics initiatives.

Journal of applied clinical medical physics·2026
Same journal

Unveiling the procoagulant state in Alzheimer's disease: A novel PET imaging strategy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Estimated labor market outcomes of people progressing from preclinical to early-stage Alzheimer's disease in the United States.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Amyloid exacerbates tau and alpha-synuclein pathologies, behavioral impairments, and neuroinflammation in a mixed dementia model.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Multimorbidity burden and patterns associated with DeepBrainNet-derived brain-age gap in dementia-free older adults: A community-based study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Reply to "Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities".

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
See all related articles

Related Experiment Video

Updated: May 24, 2026

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing
06:58

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Published on: January 24, 2020

Intraindividual cognitive decline using a brief computerized cognitive screening test.

David G Darby1, Robert H Pietrzak, Julia Fredrickson

  • 1CogState Ltd, Melbourne, Victoria, Australia. ddarby@cogstate.com

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|March 13, 2012
PubMed
Summary
This summary is machine-generated.

Detecting cognitive decline in healthy older adults may signal early Alzheimer's disease. This study identified individuals with significant memory decline, suggesting potential for early disease detection.

More Related Videos

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
10:13

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

Related Experiment Videos

Last Updated: May 24, 2026

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing
06:58

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Published on: January 24, 2020

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
10:13

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

Area of Science:

  • Neuroscience
  • Gerontology
  • Cognitive Psychology

Background:

  • Progressive intraindividual decline in memory and cognition is a hallmark of dementia.
  • Such decline may serve as an early indicator for Alzheimer's disease (AD) pathology.

Purpose of the Study:

  • To evaluate the rate of cognitive performance change over 12 months in healthy older adults.
  • To identify individuals exhibiting greater than expected cognitive decline.

Main Methods:

  • 263 healthy community-dwelling adults aged ≥50 years were assessed.
  • A computerized cognitive test battery (CogState) was administered at baseline and 3, 6, 9, and 12 months.
  • Linear mixed models analyzed age-adjusted mean slopes and confidence intervals for cognitive measures.

Main Results:

  • Individuals with decline below the fifth percentile were identified using age-adjusted mean slopes.
  • Four individuals underwent comprehensive evaluations.
  • None met criteria for mild cognitive impairment, but 75% showed positive amyloid-PET scans.

Conclusions:

  • Intraindividual cognitive decline is detectable in healthy older adults.
  • This decline warrants further investigation as a potential biomarker for early Alzheimer's disease pathology.