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A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia
Published on: September 16, 2017
Evaluating effects of normobaric oxygen therapy in acute stroke with MRI-based predictive models
Ona Wu1, Thomas Benner, Luca Roccatagliata
1Department of Neurology, Massachusetts General Hospital, 55 Fruit Street, Boston MA 02114, USA. asinghal@partners.org.
Medical Gas Research
|March 13, 2012
Summary
Normobaric oxygen therapy (NBO) may reduce lesion growth in acute ischemic stroke patients. MRI-based algorithms showed attenuated lesion expansion during NBO treatment, suggesting therapeutic potential for this stroke intervention.
Area of Science:
- Neurology
- Radiology
- Biomedical Engineering
Background:
- Acute stroke management relies on predicting tissue outcome.
- Multiparametric MRI and voxel-based algorithms show promise in stroke outcome prediction.
- Investigating novel treatments like normobaric oxygen therapy (NBO) requires objective assessment methods.
Purpose of the Study:
- To evaluate the efficacy of normobaric oxygen therapy (NBO) in acute ischemic stroke.
- To assess the utility of MRI-based predictive algorithms in evaluating NBO treatment effects.
- To explore the potential of NBO in attenuating ischemic lesion growth.
Main Methods:
- A pilot study involving 11 patients randomized to NBO and 8 controls receiving room-air.
- Serial MRI scans (diffusion/perfusion) acquired at multiple time points.
- Generalized linear models applied to pre-therapy MRI data to predict lesion growth under NBO vs. control conditions.
Main Results:
- Control-model predictions of lesion volume during NBO therapy were significantly larger than NBO-model predictions (P = 0.007).
- This suggests that ischemic lesion growth is attenuated during NBO treatment.
- NBO-treated patients exhibited reduced lesion growth compared to control predictions, though no significant differences were found at later time points.
Conclusions:
- Normobaric oxygen therapy (NBO) demonstrates therapeutic potential for acute ischemic stroke.
- MRI-based predictive algorithms are feasible for evaluating novel stroke treatments in early clinical trials.
- This approach facilitates objective assessment of treatment effects on lesion dynamics.
