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Related Experiment Video

Updated: May 24, 2026

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)

Published on: April 7, 2021

RDS--CPAP or surfactant or both.

¹Department of Neonatology, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden. kajsa.bohlin@ki.se

Acta Paediatrica (Oslo, Norway : 1992)

|March 13, 2012

Summary

This summary is machine-generated.

Early continuous positive airway pressure (CPAP) is safe for preterm infants. A surfactant strategy is crucial for those at risk of respiratory distress syndrome (RDS) when using non-invasive ventilation.

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Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)

Published on: April 7, 2021

Intratracheal Instillation of Stem Cells in Term Neonatal Rats

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Published on: May 4, 2020

Area of Science:

Neonatal Medicine
Pediatric Respiratory Care

Background:

Early continuous positive airway pressure (CPAP) is increasingly recognized as a safe and feasible intervention for very preterm infants.
Respiratory distress syndrome (RDS) remains a significant concern, often necessitating surfactant treatment even with early CPAP.
Optimizing surfactant administration alongside non-invasive ventilation is critical but requires further investigation.

Purpose of the Study:

To evaluate the safety and efficacy of early CPAP in very preterm neonates.
To explore strategies for surfactant administration within a non-invasive ventilation approach.
To identify optimal methods for surfactant delivery and the utility of predictive tests for surfactant deficiency.

Main Methods:

Review of current evidence on early CPAP in very preterm infants.
Analysis of strategies for surfactant administration in conjunction with non-invasive ventilation.
Discussion of optimal timing, delivery modes, and predictive testing for surfactant deficiency.

Main Results:

Early CPAP demonstrates comparable safety to routine intubation in the delivery room for very preterm infants.
A significant proportion of infants receiving early CPAP still require surfactant treatment for RDS.
The optimal approach involves integrating surfactant administration into non-invasive ventilation strategies for high-risk infants.

Conclusions:

Early CPAP is a safe alternative to delivery room intubation for very preterm neonates.
A proactive strategy for surfactant administration is essential for infants at risk of significant RDS when utilizing non-invasive ventilation.
Further research is needed to refine surfactant administration protocols and predictive testing.