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Regulation of the Unfolded Protein Response01:31

Regulation of the Unfolded Protein Response

Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
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Covalently Linked Protein Regulators02:04

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Related Experiment Video

Updated: May 24, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

WTX: an unexpected regulator for p53.

Chao Dai1, Wei Gu

  • 1Institute for Cancer Genetics, College of Physicians and Surgeons, Columbia University, 1130 Saint Nicholas Avenue, New York, NY 10032, USA.

Molecular Cell
|March 13, 2012
PubMed
Summary
This summary is machine-generated.

Wilms tumor suppressor WTX regulates p53 acetylation, impacting tumor suppression. WTX also affects the oncogenic β-catenin pathway, showing differential pathway regulation.

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Published on: March 21, 2022

Area of Science:

  • Molecular biology
  • Cancer research
  • Genetics

Background:

  • Wilms tumor is often associated with loss or mutation of the WTX gene.
  • WTX plays a role in regulating cellular pathways critical to tumor development.

Discussion:

  • Kim et al. (2012) elucidate WTX's role in modulating p53 tumor-suppressor activity.
  • WTX influences p53 through the regulation of its acetylation.
  • This finding highlights a novel mechanism in p53 pathway regulation.

Key Insights:

  • WTX directly impacts the acetylation status of the p53 protein.
  • This modulation affects p53's function as a tumor suppressor.
  • WTX acts as a critical regulator in both oncogenic and tumor-suppressing pathways.

Outlook:

  • Further research into WTX-p53 interactions could reveal new therapeutic targets for Wilms tumor.
  • Understanding WTX's dual role may offer insights into broader cancer mechanisms.
  • Investigating WTX's impact on acetylation provides a basis for targeted drug development.