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Related Experiment Video

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Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

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An association between affective lability and executive functioning in bipolar disorder.

Sofie Ragnhild Aminoff¹, Jimmy Jensen, Trine Vik Lagerberg

¹Institute of Clinical Medicine, University of Oslo. P O Box 1171 Blindern, N-0318 Oslo, Norway. s.r.aminoff@medisin.uio.no

Psychiatry Research

|March 13, 2012

Summary

Patients with bipolar disorder (BD) exhibit greater affective lability than healthy individuals. This heightened emotional instability in BD is linked to specific executive function deficits, particularly in semantic set shifting.

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Area of Science:

Neuroscience
Psychiatry
Cognitive Psychology

Background:

Altered affect regulation, including affective lability, is observed in bipolar disorder (BD) across different mood states.
Dysfunctional interactions between cognitive and emotional brain networks are hypothesized to underlie these regulatory issues.

Purpose of the Study:

To investigate affective lability in patients with BD compared to healthy controls (HC).
To examine the relationship between affective lability and executive functioning in BD.

Main Methods:

Affective Lability Scale (ALS) was used to measure affective lability.
Comparison between BD (N=32) and HC (N=60) groups.
Executive functioning assessment, including semantic set shifting.

Main Results:

Patients with BD showed significantly higher ALS scores than HC, indicating greater affective lability.
A positive relationship was found between affective lability and semantic set shifting in the BD group only.
Affective lability in BD appears to be both a trait and state-dependent characteristic.

Conclusions:

Elevated affective lability is a characteristic feature of bipolar disorder.
Aberrant interactions between cognitive and emotional networks may contribute to affective lability in BD.
Executive function, specifically set shifting, is impaired in relation to affective lability in BD.