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Published on: February 4, 2017
Preparation of [In-111]-labeled-DTPA-bombesin conjugates at high specific activity and stability: evaluation of
P B Pujatti1, A V F Massicano, J Mengatti
1Directory of Radiopharmacy, Nuclear and Energy Research Institute, Cidade Universitária da USP - Butantã, São Paulo, Brazil. pujatti.pb@gmail.com
Abstract:
The aim of the present work was to obtain stabilized high specific activity (HSA) (111)In-labeled bombesin conjugates for preclinical evaluations. Parameters influencing the kinetics of labeling were investigated and the effect of stabilizers on HSA radiopeptides stability at room temperature were systematically categorized applying chromatography techniques. A SA of 174 GBq/μmol was achieved with high radiochemical purity, but the labeled compounds exhibited low stability. The addition of stabilizers avoided their radiolysis and significantly increased their stability.
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