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Updated: May 24, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
Relevance of systems pharmacology in drug discovery
Lourdes Cucurull-Sanchez1, Karen G Spink, Sterghios Athanasios Moschos
1Translational Research, Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer PGRD, Sandwich, Kent CT13 9NJ, UK. Lourdes.Cucurull-Sanchez@Pfizer.com
Abstract:
The pharmaceutical industry is in the process of re-inventing its pipeline in an attempt to overcome its increasing phase II and III attrition rates. Here, we describe how systems pharmacology can be used as a risk assessment tool to alleviate this problem before bringing in larger investments. We propose that this translational research tool could provide a valuable, complementary addition to other emerging innovative approaches for target identification and validation in discovery and, ultimately, for aiding clinical trial optimization.
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