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Related Concept Videos

Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Standards of Care II01:19

Standards of Care II

Nurses bear specific legal responsibilities under several federal statutes, including:
Standards of Care I01:22

Standards of Care I

Federal statutes profoundly impact nursing practice, providing critical guidelines to ensure patient care is equitable, accessible, and of the highest quality. The following laws address distinct aspects of healthcare provision and patient rights:
Nursing Clinical Information System01:27

Nursing Clinical Information System

Nursing Clinical Information System (NCIS)
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:
Pre-Procedural Guidelines for Assessing Blood Pressure01:10

Pre-Procedural Guidelines for Assessing Blood Pressure

Accurate blood pressure assessment is crucial for diagnosing and managing various health conditions. To ensure the reliability of these measurements, healthcare professionals must adhere to standardized pre-procedural guidelines. These guidelines enhance patient safety and improve the overall quality of healthcare. The following steps are essential for obtaining accurate and consistent blood pressure readings, from using the appropriate tools to ensuring effective communication with the patient.

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Related Experiment Video

Updated: May 24, 2026

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
10:28

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function

Published on: March 15, 2022

Introducing GRADE across the NICE clinical guideline program.

Judith Thornton1, Philip Alderson, Toni Tan

  • 1Centre for Clinical Practice, National Institute for Health and Clinical Excellence, City Tower, Piccadilly Plaza, Manchester M1 4BD, United Kingdom. judith.thornton@nice.org.uk

Journal of Clinical Epidemiology
|March 13, 2012
PubMed
Summary
This summary is machine-generated.

The Grading of Recommendations Assessment, Development and Evaluation (GRADE) system enhances guideline development by separating evidence quality from recommendation strength. Implementation requires a shift in thinking, leading to more transparent decision-making.

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Last Updated: May 24, 2026

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
10:28

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function

Published on: March 15, 2022

Area of Science:

  • Health Technology Assessment
  • Clinical Practice Guidelines
  • Evidence-Based Medicine

Background:

  • The Grading of Recommendations Assessment, Development and Evaluation (GRADE) system is used for rating evidence confidence and guideline recommendations.
  • It involves evaluating evidence quality and balancing outcomes to determine recommendation strength.
  • The National Institute for Health and Clinical Excellence (NICE) adopted GRADE in 2007.

Purpose of the Study:

  • To describe the implementation process of the GRADE system across clinical guidelines.
  • To assess the reception and impact of GRADE adoption.

Main Methods:

  • Implementation of the GRADE system across guideline development processes.
  • Qualitative assessment of feedback from technical staff and guideline development group members.

Main Results:

  • The GRADE system was positively received by both technical staff and guideline development group members.
  • Implementation necessitated a conceptual shift towards structured and transparent decision-making.

Conclusions:

  • A shift in thinking regarding evidence confidence is required for structured, transparent decision-making.
  • Practical challenges were encountered and largely resolved, though areas like imprecision and multi-intervention analyses need further work.
  • Refinement is needed for applying GRADE to non-randomized and diagnostic accuracy studies.