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Updated: May 24, 2026

Whole Mount Labeling of Cilia in the Main Olfactory System of Mice
Published on: December 27, 2014
Dense representation of natural odorants in the mouse olfactory bulb
Roberto Vincis1, Olivier Gschwend, Khaleel Bhaukaurally
1Department of Basic Neurosciences, School of Medicine, University of Geneva, Geneva, Switzerland.
Abstract:
In mammals, odorant molecules are thought to activate only a few glomeruli, leading to the hypothesis that odor representation in the olfactory bulb is sparse. However, the studies supporting this model used anesthetized animals or monomolecular odorants at limited concentration ranges. Using optical imaging and two-photon microscopy, we found that natural odorants at their native concentrations could elicit dense representations in the olfactory bulb. Both anesthesia and odorant concentration were found to modulate the representation density of natural odorants.
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