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Fragrance material review on phenethyl formate
D McGinty1, C S Letizia, A M Api
1Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA. dmcginty@RIFM.org
This review examines phenethyl formate, an Aryl Alkyl Alcohol Simple Acid Ester (AAASAE) fragrance ingredient. Data on its toxicology and dermatology were summarized to assess safety for cosmetic use.
Area of Science:
- Toxicology
- Dermatology
- Fragrance Ingredient Safety
Background:
- Phenethyl formate belongs to the Aryl Alkyl Alcohol Simple Acid Esters (AAASAE) group.
- AAASAEs are synthesized by esterifying aryl alkyl alcohols with short-chain carboxylic acids.
- This review focuses on phenethyl formate as a specific fragrance ingredient.
Purpose of the Study:
- To conduct a toxicologic and dermatologic review of phenethyl formate.
- To summarize available data on phenethyl formate's safety profile.
- To inform the overall safety assessment of AAASAE fragrance ingredients.
Main Methods:
- Compilation and evaluation of existing toxicology and dermatology studies.
- Analysis of physical properties, acute toxicity, skin irritation, and sensitization data.
- Assessment of genotoxicity data for phenethyl formate.
Main Results:
- Summarized available data on phenethyl formate's physical properties and toxicological endpoints.
- Included data on acute toxicity, skin irritation, and skin sensitization.
- Evaluated genotoxicity data relevant to fragrance ingredient safety.
Conclusions:
- Phenethyl formate data were evaluated and summarized.
- This review is part of a larger safety assessment of AAASAE fragrance ingredients.
- Refer to Belsito et al. (2012) for a comprehensive safety assessment of AAASAEs.
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