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Related Experiment Video

Updated: May 24, 2026

Imaging Cell Shape Change in Living Drosophila Embryos

Imaging Cell Shape Change in Living Drosophila Embryos

Published on: March 30, 2011

Effectors of tridimensional cell morphogenesis and their evolution.

Hélène Chanut-Delalande¹, Pierre Ferrer, François Payre

¹Université de Toulouse, UPS, Centre de Biologie du Développement, Toulouse, France.

Seminars in Cell & Developmental Biology

|March 13, 2012

Summary

Understanding how genomes regulate cell shape is crucial for development. This review explores genes controlling cell shape changes in Drosophila and their link to human hereditary deafness.

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Optogenetic Inhibition of Rho1-Mediated Actomyosin Contractility Coupled with Measurement of Epithelial Tension in Drosophila Embryos

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Published on: April 14, 2023

Area of Science:

Cellular biology
Developmental biology
Genetics

Background:

Cellular architecture relies on cytoskeletal networks, but in vivo models are needed to understand developmental cell shape changes.
The development of Drosophila epidermis offers a genetic model to identify cell shape remodeling mechanisms.
Genes involved in hereditary deafness in humans highlight factors crucial for apical cell extensions like stereocilia.

Purpose of the Study:

To review recent findings on genes controlling localized cell shape changes.
To discuss the evolutionary conservation of these genes across species and developmental processes.

Main Methods:

Genetic analysis in Drosophila epidermis.
Mapping of human genes associated with hereditary deafness.

Main Results:

Identification of genes regulating epidermal cell shape remodeling for trichome formation.
Discovery of conserved factors involved in apical cell extensions.

Conclusions:

Genes controlling cell shape are vital for tissue development and have evolutionary significance.
Studying diverse models like Drosophila and human genetics provides insights into fundamental biological processes.