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Updated: May 24, 2026

Establishing 3D Endometrial Organoids from the Mouse Uterus
Published on: January 6, 2023
Diverse functions of uterine proteoglycans in human reproduction (review)
Kotaro Kitaya1, Yoshihiro Tada, Terumi Hayashi
1IVF Center, Oak Clinic, Osaka, Japan.
Abstract:
Proteoglycans (PGs) are a group of heavily glycosylated proteins that are present throughout the mammalian body and are involved in a wide variety of biological phenomena, including structural maintenance, tissue remodeling, molecular presentation, cell adhesion and signal transmission. Previous studies have revealed an increasing number of roles for PGs in human reproduction. Several PGs are currently utilized or regarded as biomarkers for the diagnosis of certain pathological uterine conditions associated with infertility and obstetrical complications. The aim of this review was to discuss the involvement of PGs in the human uterus in reproductive biology and pathophysiology.
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