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Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
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Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis
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Published on: October 13, 2023

Childhood trauma in multiple sclerosis: a case-control study.

Carsten Spitzer1, Miriam Bouchain, Liza Y Winkler

  • 1Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Hamburg-Eppendorf and Schön Klinik Hamburg-Eilbek, Martinistr. 52, 20246 Hamburg, Germany. c.spitzer@uke.uni-hamburg.de

Psychosomatic Medicine
|March 13, 2012
PubMed
Summary
This summary is machine-generated.

Childhood trauma, including emotional abuse and neglect, is associated with a higher risk of developing multiple sclerosis (MS). Early-life stress may also increase relapse rates in individuals with MS.

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Published on: July 19, 2019

Area of Science:

  • Neuroimmunology
  • Psychoneuroimmunology
  • Epidemiology

Background:

  • Childhood trauma has long-term health consequences.
  • Previous research links emotional stressors to multiple sclerosis (MS).
  • The specific impact of childhood trauma on MS risk remains understudied.

Purpose of the Study:

  • To investigate the association between childhood trauma and MS.
  • To compare childhood abuse and neglect histories in MS patients versus the general population.

Main Methods:

  • Cross-sectional case-control study.
  • Utilized the self-reported Childhood Trauma Questionnaire.
  • Assessed 234 MS patients and 885 general population adults.

Main Results:

  • MS patients reported significantly higher emotional abuse and neglect than controls.
  • Higher odds of emotional neglect (OR=2.0) and emotional abuse (OR=3.4) in MS patients.
  • Childhood trauma history correlated with higher MS relapse rates, but not disability.

Conclusions:

  • Findings suggest a link between childhood trauma and MS.
  • Further longitudinal studies are needed to confirm the relationship between early-life stress and MS risk.