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Radical Autoxidation

The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...
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Updated: May 24, 2026

Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors
09:33

Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors

Published on: February 7, 2018

Antioxidant-induced stress.

Cleva Villanueva1, Robert D Kross2

  • 1Escuela Superior de Medicina del IPN, Posgrado e Investigacion, Plan de San Luis y Salvador Diaz Miron S/N, Colonia Casco de Santo Tomas, Mexico, DF. 11340, Mexico.

International Journal of Molecular Sciences
|March 13, 2012
PubMed
Summary

Antioxidants, popular health products, may cause harm by disrupting the body's natural balance. This review explores the potential for "antioxidant-induced stress" when antioxidants overwhelm free radicals.

Keywords:
antioxidantharmful effectsoxidative stress

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Area of Science:

  • Biochemistry
  • Health Sciences
  • Pharmacology

Background:

  • Antioxidants are widely used as popular health-protecting supplements.
  • Extensive research highlights antioxidant benefits, yet potential adverse effects are less explored.
  • A delicate balance exists between antioxidants and free radicals in the human body.

Purpose of the Study:

  • To analyze existing evidence on the adverse effects of antioxidants.
  • To present a hypothesis regarding potential harm from antioxidant supplementation.
  • To investigate the concept of "antioxidant-induced stress".

Main Methods:

  • Literature review of scientific evidence on antioxidant effects.
  • Analysis of studies examining the balance between antioxidants and free radicals.
  • Synthesis of findings to formulate a hypothesis on antioxidant-induced stress.

Main Results:

  • Evidence suggests that antioxidants, while beneficial, can have harmful effects.
  • The normal physiological balance between oxidants and antioxidants can be disrupted.
  • A state of "antioxidant-induced stress" may occur when antioxidant levels are excessive.

Conclusions:

  • Excessive intake of antioxidants can potentially lead to adverse health outcomes.
  • The hypothesis of "antioxidant-induced stress" warrants further investigation.
  • A balanced approach to antioxidant supplementation is crucial for maintaining health.