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Related Concept Videos

Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Cardiomyopathy VII: Pre and Post Operative Nursing Management01:28

Cardiomyopathy VII: Pre and Post Operative Nursing Management

Patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction who remain symptomatic despite optimal medical therapy may undergo a septal myectomy (Morrow procedure). This procedure involves excising a portion of the hypertrophied septum below the aortic valve using a heart-lung machine to improve blood flow through the LVOT. Effective preoperative and postoperative nursing management ensures successful patient outcomes, minimizes complications, and...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Aneurysm IV: Nursing Management01:22

Aneurysm IV: Nursing Management

Vigilant monitoring for aneurysm rupture is essential for patients undergoing aortic surgery.Preoperative Nursing ManagementContinuously monitor the patient for manifestations of aneurysm rupture, such as pallor, weakness, tachycardia, hypotension, abdominal, back, groin, or periumbilical pain, changes in consciousness, and a pulsating abdominal mass. Regularly assess the patient's peripheral pulses.Instruct the patient to consume a clear liquid diet the day before surgery and administer...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

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Related Experiment Video

Updated: May 24, 2026

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies
07:15

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies

Published on: July 28, 2020

Surgical considerations in patients receiving neoadjuvant systemic therapy.

Akhil Chawla1, Kelly K Hunt, Elizabeth A Mittendorf

  • 1Department of Surgery, Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH, USA.

Future Oncology (London, England)
|March 14, 2012
PubMed
Summary

Neoadjuvant chemotherapy helps shrink operable breast tumors, enabling breast-conserving surgery. Axillary lymph node management in these patients depends on initial lymph node status, with ongoing trials exploring sentinel lymph node biopsy for node-positive cases.

Related Experiment Videos

Last Updated: May 24, 2026

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies
07:15

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies

Published on: July 28, 2020

Area of Science:

  • Oncology
  • Surgical Oncology
  • Breast Cancer Research

Background:

  • Neoadjuvant chemotherapy is increasingly utilized for early-stage, operable breast cancer.
  • This treatment can reduce tumor size, facilitating breast-conserving therapy for selected patients.

Purpose of the Study:

  • To outline the current management strategies for the axilla in breast cancer patients undergoing neoadjuvant chemotherapy.
  • To highlight the evolving role of sentinel lymph node dissection and axillary lymph node dissection based on clinical nodal status.

Main Methods:

  • Review of current clinical practices and guidelines for axillary staging in breast cancer patients receiving neoadjuvant chemotherapy.
  • Discussion of an ongoing cooperative group trial evaluating sentinel lymph node surgery in clinically node-positive patients.

Main Results:

  • For clinically node-negative patients, sentinel lymph node dissection is performed post-chemotherapy, with axillary lymph node dissection reserved for positive sentinel nodes.
  • Clinically node-positive patients currently undergo axillary lymph node dissection as standard care.

Conclusions:

  • Axillary management following neoadjuvant chemotherapy is stratified by initial nodal status.
  • Further research, including ongoing trials, is crucial to refine surgical approaches for the axilla, particularly in node-positive breast cancer patients.