Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

26.4K
Overview
26.4K
Allergic Drug Reactions01:27

Allergic Drug Reactions

1.6K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.6K
Autoimmune Disorders01:29

Autoimmune Disorders

2.4K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
2.4K
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

209
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
209
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

280
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
280
Asthma I: Introduction01:28

Asthma I: Introduction

112
Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
112

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Health care professionals' confidence in recognising different skin conditions presented in primary care: a cross-sectional survey.

Clinical and experimental dermatology·2026
Same author

Translating the Eczema Bathing Study: why context and infection burden matter: reply from authors.

The British journal of dermatology·2026
Same author

Core outcome sets: What are they and why they matter.

The Journal of investigative dermatology·2026
Same author

Three-Year Follow-Up of the PACI Randomized Controlled Trial (PACI-ON): Effects of Early Intervention for Atopic Dermatitis on Atopic March.

Allergy·2026
Same author

Adverse Effects of Moisturizers Should Be Considered in Eczema Studies-Reply.

JAMA dermatology·2026
Same author

Nicotinamide for Skin Cancer Chemoprevention: The Jury Was Out and Still is.

American journal of clinical dermatology·2026

Related Experiment Video

Updated: May 4, 2026

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
06:47

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

Published on: September 27, 2017

9.3K

Does "autoreactivity" play a role in atopic dermatitis?

Ting Seng Tang1, Thomas Bieber, Hywel C Williams

  • 1Centre of Evidence Based Dermatology, University of Nottingham, Nottingham, United Kingdom.

The Journal of Allergy and Clinical Immunology
|March 14, 2012
PubMed
Summary

Autoreactivity, an immune response to the body's own proteins, is frequently observed in atopic dermatitis (AD) patients. This suggests a potential role for autoimmunity in causing AD, warranting further investigation into its chronic nature.

More Related Videos

Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System
10:25

Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System

Published on: September 20, 2019

6.5K
A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
08:02

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

5.3K

Related Experiment Videos

Last Updated: May 4, 2026

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
06:47

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

Published on: September 27, 2017

9.3K
Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System
10:25

Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System

Published on: September 20, 2019

6.5K
A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
08:02

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

5.3K

Area of Science:

  • Immunology
  • Dermatology
  • Autoimmunity

Background:

  • The role of autoimmunity in atopic dermatitis (AD) pathogenesis remains unclear.
  • Understanding autoreactivity in AD is crucial for developing targeted therapies.

Purpose of the Study:

  • To systematically review the occurrence and correlation of autoreactivity with AD severity.
  • To investigate the potential causative role of autoreactivity in AD.

Main Methods:

  • Systematic review of 31 studies from MEDLINE involving patients with AD.
  • Definition of autoreactivity as an immune response to self-proteins or tissues.
  • Analysis of prevalence, correlation with severity, and comparison with other diseases.

Main Results:

  • Autoreactivity prevalence in AD patients ranged from 23% to 91%.
  • Autoreactivity was specific to AD, not found in healthy controls or other inflammatory conditions.
  • A positive correlation was observed between autoreactivity and AD severity.

Conclusions:

  • Autoreactivity, particularly IgE and IgG autoantibodies and T(H)1 responses, may play a causative role in AD.
  • Further longitudinal studies are needed to determine if autoantibodies contribute to AD chronicity.