Related Experiment Video

Updated: May 24, 2026

Enhancing Prostate Tumor Biobanking Reliability with Improved Sampling Technique and Histological Characterization
07:34

Enhancing Prostate Tumor Biobanking Reliability with Improved Sampling Technique and Histological Characterization

Published on: November 17, 2023

Personalized management of patients with solid cancers: moving from patient characteristics to tumor biology

Ahmad Awada1, Anna M Vandone, Philippe Aftimos

  • 1Medical Oncology Clinic, Institut Jules Bordet-Université libre de Bruxelles, Brussels, Belgium. ahmad.awada@bordet.be

Current Opinion in Oncology
|March 14, 2012
PubMed
Abstract

Insights

Personalized cancer care is now a reality thanks to advances in molecular biology. This approach improves cancer subtyping, risk definition, and treatment prediction for better outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genomics

Background:

  • Solid tumor diagnosis and treatment have undergone significant changes.
  • Historically refractory cancers are now being re-evaluated.
  • Molecular biology advances are revolutionizing cancer management.

Purpose of the Study:

  • To review recent findings in cancer subtyping and treatment.
  • To highlight progress in managing historically difficult-to-treat cancers.
  • To discuss the shift towards personalized cancer care.

Main Methods:

  • Review of recent scientific literature.
  • Analysis of advances in molecular biology and genomics.
  • Integration of molecular markers and gene signatures in risk assessment.

Main Results:

  • Personalized cancer management has rapidly developed.
  • Molecular markers and gene signatures enhance risk definition and treatment prediction.
  • New hope for treating melanoma, non-small cell lung cancer, and orphan tumors.

Conclusions:

  • Laboratory discoveries have translated to clinical practice, making personalized cancer care a reality.
  • Molecularly selected patient enrollment in clinical trials is increasing.
  • This approach is expected to improve clinical trial success rates.

More Related Videos

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors11:15

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cancer Survival Analysis01:21

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...