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Updated: May 24, 2026
The Miniature Pig: A Large Animal Model for Cochlear Implant Research
Published on: July 28, 2022
Sheep as a large animal model for middle and inner ear implantable hearing devices: a feasibility study in cadavers
Johannes Schnabl1, Rudolf Glueckert, Gudrun Feuchtner
1Department of Otolaryngology, University Hospital, Medical University Innsbruck, Innsbruck, Austria.
Objective:
Currently, no large animal model exists for surgical-experimental exploratory analysis of implantable hearing devices. In a histomorphometric study, we sought to investigate whether sheep or pig cochleae are suitable for this purpose and whether device implantation is feasible.
Methods:
Skulls of pig and sheep cadavers were examined using high-resolution 128-slice computed tomography (CT) to study anatomic relationships. A cochlear implant and an active middle ear implant could be successfully implanted into the sheep's inner and middle ear, respectively. Correct device placement was verified by CT and histology. The cochlear anatomy of the sheep was further studied by micro-CT and histology.
Results:
Our investigations indicate that the sheep is a suitable animal model for implantation of implantable hearing devices. The implantation of the devices was successfully performed by access through a mastoidectomy. The histologic, morphologic, and micro-CT study of the sheep cochlea showed that it is highly similar to the human cochlea. The temporal bone of the pig was not suitable for these microsurgical procedures because the middle and inner ear were not accessible owing to distinct soft and fatty tissue coverage of the mastoid.
Conclusion:
The sheep is an appropriate large animal model for experimental studies with implantable hearing devices, whereas the pig is not.
