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Related Experiment Video

Updated: May 24, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

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[Sleep-disordered breathing and cardiac resynchronization therapy].

¹Klinik für Kardiologie, Pneumologie und Internistische Intensivmedizin, Sana Klinikum Hof, Eppenreuther Str. 9, 95032, Hof, Deutschland. anil-martin.sinha@klinikumhof.de

Herzschrittmachertherapie & Elektrophysiologie

|March 14, 2012

Summary

This summary is machine-generated.

Cardiac resynchronization therapy (CRT) improves heart failure and sleep apnea, but not obstructive sleep apnea. Patients with heart failure should be monitored for sleep-disordered breathing before and after CRT.

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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

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Area of Science:

Cardiology
Sleep Medicine
Pulmonology

Context:

Progressive heart failure frequently co-occurs with sleep-disordered breathing (SDB).
Cardiac resynchronization therapy (CRT) is a treatment for heart failure.
The impact of CRT on various types of sleep apnea requires further investigation.

Purpose:

To evaluate the effects of CRT on sleep-disordered breathing (SDB) in patients with progressive heart failure.
To assess the influence of CRT on central sleep apnea syndrome (CSA) with Cheyne-Stokes respiration and obstructive sleep apnea syndrome (OSAS).
To determine the long-term impact of CRT on sleep quality, depressive symptoms, and survival.

Summary:

CRT improved cardiac function and central sleep apnea syndrome (CSA) with Cheyne-Stokes respiration.
CRT showed no significant clinical relevance for obstructive sleep apnea syndrome (OSAS).
Additional atrial overdrive pacing did not enhance CRT's effects on CSA.
CRT led to improved sleep parameters, enhanced sleep quality, reduced depressive syndromes, and improved long-term survival.

Impact:

CRT is beneficial for heart failure patients with SDB, particularly CSA.
Monitoring for SDB before and after CRT implantation is recommended for all chronic heart failure patients.
Further research may explore optimizing CRT settings or adjunctive therapies for OSAS in heart failure patients.