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Meningioma as second malignant neoplasm after oncological treatment during childhood

H L Müller1, U Gebhardt, M Warmuth-Metz

  • 1Department of Pediatric Hematology and Oncology, Zentrum für Kinder- und Jugendmedizin, Klinikum Oldenburg, Rahel-Straus-Str. 10, 26133, Oldenburg, Germany. mueller.hermann@klinikum-oldenburg.de

Strahlentherapie Und Onkologie : Organ Der Deutschen Rontgengesellschaft ... [Et Al]
|March 14, 2012
PubMed

Insights

Childhood cancer survivors exposed to radiation therapy may develop meningioma as a second malignant neoplasm (SMN). High-dose radiation increases the risk of SMN meningioma with a short latency period.

Area of Science:

  • Pediatric Oncology
  • Neuro-oncology
  • Radiation Oncology

Background:

  • Childhood meningioma is a rare primary brain tumor.
  • Understanding the risk of secondary meningioma in childhood cancer survivors is crucial.

Observation:

  • A German registry identified 38 patients with childhood meningioma.
  • Five cases (13%) were secondary malignant neoplasms (SMNs), diagnosed at a median age of 12.4 years.
  • These SMNs occurred after primary malignancies (e.g., brain tumors, leukemia) treated with radiation (12-54 Gy).

Findings:

  • Median latency for SMN meningioma was 10.2 years after primary malignancy.
  • Histologies included WHO grades I, II, and III.
  • Treatment outcomes for SMN meningioma were generally favorable (4/5 patients), with one death.

Implications:

  • Childhood cancer survivors treated with radiation are at risk for developing meningioma as a SMN.
  • High-dose radiation and young age at exposure are associated with a shorter latency period for SMN meningioma.
  • Long-term surveillance for secondary neoplasms in pediatric cancer survivors is warranted.

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