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Related Concept Videos

Nephrons01:10

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma happens...
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
External Anatomy of the Kidney01:21

External Anatomy of the Kidney

The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...

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Related Experiment Video

Updated: May 24, 2026

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
07:35

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

Published on: June 23, 2015

[Cystic kidney diseases].

K Zerres1, N Ortiz Brüchle

  • 1Institut für Humangenetik, Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen. kzerres@ukaachen.de

Der Internist
|March 14, 2012
PubMed
Summary

Cystic kidney diseases, including polycystic kidney diseases, are linked to primary cilia dysfunction. Accurate diagnosis relies on clinical, imaging, and genetic factors for effective patient care and genetic counseling.

Area of Science:

  • Nephrology
  • Genetics
  • Cell Biology

Context:

  • Cystic kidney diseases are a diverse group of disorders.
  • Autosomal-dominant and autosomal-recessive polycystic kidney diseases are the most prevalent forms.
  • These conditions are increasingly recognized as ciliopathies, involving defects in primary cilia.

Purpose:

  • To highlight the genetic heterogeneity and clinical significance of cystic kidney diseases.
  • To emphasize the role of primary cilia and cystoproteins in disease pathogenesis.
  • To outline the diagnostic approach for inherited polycystic kidney diseases.

Summary:

  • Cystic kidney diseases, primarily polycystic kidney diseases, involve genetic mutations affecting cystoproteins in primary cilia.
  • Primary cilia are crucial for preventing cyst formation, and their dysfunction links these diseases to ciliopathies.

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Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium

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Evaluation of Zebrafish Kidney Function Using a Fluorescent Clearance Assay
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Evaluation of Zebrafish Kidney Function Using a Fluorescent Clearance Assay

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Related Experiment Videos

Last Updated: May 24, 2026

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
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Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

Published on: June 23, 2015

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium
08:46

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium

Published on: September 1, 2015

Evaluation of Zebrafish Kidney Function Using a Fluorescent Clearance Assay
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Evaluation of Zebrafish Kidney Function Using a Fluorescent Clearance Assay

Published on: February 20, 2015

  • Diagnosis requires integrating clinical, ultrasonographic, morphological data, family history, and molecular genetic testing.

    • Impact:

    • Improved understanding of the molecular basis of cystic kidney diseases.
    • Enhanced diagnostic strategies for inherited polycystic kidney diseases.
    • Foundation for genetic counseling and personalized patient management.