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Related Concept Videos

Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
Type I Diabetes I: Introduction01:12

Type I Diabetes I: Introduction

Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...

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Related Experiment Video

Updated: May 24, 2026

Generation of Scaffold-free, Three-dimensional Insulin Expressing Pancreatoids from Mouse Pancreatic Progenitors In Vitro
09:33

Generation of Scaffold-free, Three-dimensional Insulin Expressing Pancreatoids from Mouse Pancreatic Progenitors In Vitro

Published on: June 2, 2018

[Genetically determined pancreatic diseases].

J Rosendahl1, J Mössner

  • 1Klinik und Poliklinik für Gastroenterologie und Rheumatologie, Department für Innere Medizin, Neurologie und Dermatologie, Universitätsklinikum Leipzig, AöR, Liebigstr. 20, 04103, Leipzig. jonas.rosendahl@medizin.uni-leipzig.de

Der Internist
|March 14, 2012
PubMed
Summary
This summary is machine-generated.

Genetic analysis is crucial for diagnosing rare pancreatic diseases like chronic pancreatitis and cystic fibrosis. Identifying genetic alterations, particularly in CFTR, enhances understanding of disease mechanisms and aids diagnosis.

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Last Updated: May 24, 2026

Generation of Scaffold-free, Three-dimensional Insulin Expressing Pancreatoids from Mouse Pancreatic Progenitors In Vitro
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Generation of Scaffold-free, Three-dimensional Insulin Expressing Pancreatoids from Mouse Pancreatic Progenitors In Vitro

Published on: June 2, 2018

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Area of Science:

  • Genetics
  • Gastroenterology
  • Pediatrics

Context:

  • Genetically determined pancreatic diseases are rare but increasingly recognized.
  • Chronic pancreatitis and cystic fibrosis share common genetic links, particularly involving the CFTR gene.
  • Rare disorders like Shwachman-Diamond syndrome and Johanson Blizzard syndrome also present with exocrine insufficiency.

Purpose:

  • To highlight the importance of genetic analysis in diagnosing various pancreatic diseases.
  • To explore the role of genetic alterations, especially in the CFTR gene, in understanding disease pathogenesis.
  • To emphasize the diagnostic utility of genetic testing and sweat chloride tests.

Summary:

  • Genetic analysis of associated genes is essential for diagnosing rare pancreatic diseases, including chronic pancreatitis, cystic fibrosis, Shwachman-Diamond syndrome, and Johanson Blizzard syndrome.
  • Alterations in the CFTR gene are implicated in both chronic pancreatitis and cystic fibrosis, improving the understanding of their pathogenetic mechanisms.
  • Genetic testing and sweat chloride tests are vital for accurate diagnosis and ruling out cystic fibrosis in patients with exocrine insufficiency.

Impact:

  • Advances genetic understanding of pancreatic diseases, improving diagnostic accuracy.
  • Establishes genetic analysis as a cornerstone for diagnosing rare pancreatic disorders.
  • Provides a foundation for future therapeutic strategies based on genetic insights.