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Use of mirabegron in treating overactive bladder.
Alka A Bhide1, G Alessandro Digesu, Ruwan Fernando
1Department of Urogynaecology, St. Mary's Hospital, Cambridge Wing, Praed Street, W1 1NY London, UK.
International Urogynecology Journal
|March 14, 2012
Summary
Mirabegron offers a new treatment for overactive bladder (OAB) by targeting beta-3 adrenoreceptors. Clinical studies show it effectively reduces OAB symptoms with mild side effects, presenting a promising alternative to existing therapies.
Area of Science:
- Pharmacology
- Urology
Background:
- Overactive bladder (OAB) lacks alternatives to antimuscarinics.
- Beta-3 adrenoreceptors in the bladder play a role in relaxation.
- Targeting these receptors can improve bladder capacity and compliance.
Purpose of the Study:
- To evaluate the efficacy and safety of mirabegron for OAB symptoms.
- To identify mirabegron as a potential alternative to antimuscarinic drugs.
Main Methods:
- MEDLINE literature search for mirabegron efficacy and safety.
- Searched clinical trial registries (ClinicalTrials.gov, controlled-trials.com) and FDA website.
- Included English-language articles and randomized controlled trials (RCTs) from scientific meetings.
Main Results:
- Mirabegron significantly reduced daily micturitions and incontinence episodes compared to placebo.
- Common side effects like dry mouth and GI disturbances were mild to moderate.
- A slight increase in heart rate and blood pressure was observed.
Conclusions:
- Mirabegron demonstrates efficacy in managing overactive bladder symptoms.
- It presents a promising alternative to antimuscarinic treatments.
- Further research is needed on long-term efficacy, safety, tolerability, and drug interactions (CYP2D6).
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