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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

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Published on: September 20, 2018

Pick's disease.

Naoya Takeda¹, Yuki Kishimoto, Osamu Yokota

¹Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Advances in Experimental Medicine and Biology

|March 14, 2012

Summary

Picks disease, a form of frontotemporal lobar degeneration (FTLD), involves brain atrophy. This chapter reviews FTLD subtypes and discusses potential future methods for diagnosing these neurodegenerative diseases before death.

Area of Science:

Neurology
Pathology
Neuroscience

Background:

Picks disease is characterized by frontotemporal lobe atrophy.
Demented patients with frontotemporal atrophy are diagnosed as frontotemporal lobar degeneration (FTLD).
FTLD encompasses various underlying pathologies including TDP-43 inclusions, corticobasal degeneration, and progressive supranuclear palsy.

Purpose of the Study:

To present recent findings on the clinical and histopathological features of FTLD subtypes.
To discuss the potential for future antemortem diagnosis of FTLD.

Main Methods:

Review of recent clinical and histopathological findings.
Discussion of diagnostic advancements.

Main Results:

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Distinct clinical and histopathological features of various FTLD entities are detailed.
The possibility of future antemortem diagnosis is explored.

Conclusions:

Understanding the distinct features of FTLD subtypes is crucial.
Advancements in diagnosis may allow for earlier and more accurate identification of FTLD.