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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
Elevated factor VIII: an unfamiliar risk factor for cerebral venous thrombosis
Nicole E Albert1, Andrew Y Hamarich, Ami Joshi
1Department of Internal Medicine, Lankenau Medical Center, 100 E Lancaster Ave, Wynnewood, PA 19096-3415, USA. albertn@mlhs.org
The Journal of the American Osteopathic Association
|March 14, 2012
Summary
Elevated factor VIII levels increase venous thrombosis risk, yet are under-screened. A case study highlights this risk in a healthy woman with cerebral venous thrombosis.
Area of Science:
- Hematology
- Vascular Medicine
- Thrombosis Research
Background:
- Elevated factor VIII levels are an independent risk factor for venous thrombosis.
- Screening for factor VIII deficiency is less common than for other coagulopathies.
- Causes of elevated factor VIII are multifactorial, involving genetic and acquired factors.
Observation:
- A healthy 48-year-old woman presented with cerebral venous thrombosis.
- No other identifiable risk factors for thrombosis were found in this patient.
Findings:
- The patient's sole identifiable risk factor was an elevated factor VIII level.
- This case underscores the clinical significance of factor VIII in thrombosis etiology.
Implications:
- Increased clinical awareness and screening for elevated factor VIII levels are warranted.
- Further research into the genetic and acquired causes of high factor VIII is needed.
- Understanding factor VIII's role may improve thrombosis prevention strategies.
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