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Sweetened beverage consumption, incident coronary heart disease, and biomarkers of risk in men
Lawrence de Koning1, Vasanti S Malik, Mark D Kellogg
1Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA.
Circulation
|March 14, 2012
Summary
Consuming sugar-sweetened beverages increases coronary heart disease (CHD) risk and negatively impacts biomarkers. Artificially sweetened beverages show no significant association with CHD or these biomarkers.
Area of Science:
- Cardiovascular Health
- Nutritional Epidemiology
- Metabolic Disease
Background:
- Sugar-sweetened beverage (SSB) intake is linked to weight gain and type 2 diabetes.
- Limited research exists on SSB association with coronary heart disease (CHD) and biomarkers.
- The impact of artificially sweetened beverages (ASB) remains unclear.
Purpose of the Study:
- To investigate the association between SSB and ASB consumption and incident CHD.
- To examine the relationship between beverage intake and intermediate biomarkers of cardiovascular risk.
Main Methods:
- Analysis of the prospective Health Professionals Follow-Up Study cohort (42,883 men).
- Examined associations of cumulative SSB and ASB intake with fatal and nonfatal CHD using proportional hazard models.
- Adjusted for numerous lifestyle, dietary, and health factors.
Main Results:
- Higher SSB intake correlated with a 20% increased relative risk of CHD.
- ASB consumption showed no significant association with CHD risk.
- SSB intake linked to adverse changes in triglycerides, inflammatory markers, and leptin; decreased HDL and lipoprotein(a).
Conclusions:
- SSB consumption is associated with elevated CHD risk and detrimental changes in lipids and inflammatory markers.
- ASB intake was not linked to increased CHD risk or adverse biomarker changes.
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