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Updated: May 24, 2026

Bone Marrow-derived Macrophage Production
Published on: November 22, 2013
Non-canonical alternatives: what a macrophage is 4
Christopher L Karp1, Peter J Murray
1Division of Molecular Immunology, Cincinnati Children's Hospital Research Foundation, Cincinnati, OH 45229, USA. chris.karp@cchmc.org
Abstract:
Macrophages play pleiotropic, niche-specific roles in all tissues and organs. As immune sentinels, tissue macrophages regulate immune activation and inflammation; in turn, their function is modulated by inflammatory mediators deriving from such activation. Recent papers have established unanticipated roles for interleukin 4 and the alternative activation of tissue macrophages in the organismal response to diverse environmental stressors.
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