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Published on: December 30, 2025

Use of thrombolytic therapy in cerebral venous sinus thrombosis with ulcerative colitis

Kavitha Kothur1, Subhash Kaul, S Rammurthi

  • 1Department of Neurology, Nizam's Institute of Medical Sciences, Panjagutta, Hyderabad, India.

Annals of Indian Academy of Neurology
|March 14, 2012
PubMed

Insights

Intracranial venous thrombosis in active ulcerative colitis is challenging. Intrasinus urokinase successfully lysed a dural venous sinus clot, resolving symptoms without bleeding.

Area of Science:

  • Neurology
  • Gastroenterology
  • Vascular Medicine

Background:

  • Cerebral venous thrombosis (CVT) concurrent with active ulcerative colitis (UC) presents a significant therapeutic challenge.
  • Management strategies for CVT in UC patients require careful consideration due to potential bleeding risks.

Observation:

  • A 31-year-old female patient presented with dural venous sinus thrombosis (DVST) during active ulcerative colitis.
  • The patient's neurological status and imaging findings were monitored closely.

Findings:

  • Successful clot lysis was achieved using intrasinus urokinase administration.
  • The treatment resulted in neurological improvement and resolution of DVST on imaging.
  • No bleeding complications were observed post-procedure.

Implications:

  • Intrasinus urokinase is a viable and safe treatment option for DVST in active UC patients.
  • This case highlights the importance of multidisciplinary management for complex thromboembolic events in inflammatory bowel disease.
  • Further literature review supports varied treatment modalities for CVT in UC, emphasizing individualized patient care.

Keywords:
Cerebral venous sinus thrombosisintrasinus urokinasethrombolytic therapyulcerative colitis

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