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Updated: May 24, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Methyl 4-{[(4-methyl-phen-yl)sulfon-yl]amino}-benzoate
Abstract:
In the mol-ecule of the title compound, C(15)H(15)NO(4)S, the dihedral angle between the two rings is 88.05 (7)°. The methyl ester group is nearly coplanar with the adjacent ring [dihedral angle = 2.81 (10)°], whereas it is oriented at 86.90 (9)° with respect to the plane of the ring attached to the -SO(2)- group. Weak intra-molecular C-H⋯O hydrogen bonding completes S(5) and S(6) ring motifs. The mol-ecules form one-dimensional polymeric C(8) chains along the [010] direction due to N-H⋯O hydrogen bonding and these chains are linked by C-H⋯O hydrogen bonds, forming a three-dimensional network.
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