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Updated: May 24, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
N'-(2-Hy-droxy-4-meth-oxy-benzyl-idene)-4-methyl-benzohydrazide
Yan Zhang1, Min Liu, Jing-Jun Ma
1Hebei Key Laboratory of Bioinorganic Chemistry, College of Sciences, Agricultural University of Hebei, Baoding 071001, People's Republic of China.
Abstract:
The asymmetric unit of the title compound, C(16)H(16)N(2)O(3), contains four independent mol-ecules with different conformations; the dihedral angles between the two benzene rings in the mol-ecules are 39.7 (3), 45.4 (3), 50.6 (3) and 51.6 (3)°. Intramolecular O-H⋯N hydrogen bonds are observed in the molecule. In the crystal, N-H⋯O hydrogen bonds link the mol-ecules into two crystallographically independent chains propagating in [010], and each chain is formed by two alternating independent mol-ecules. Weak C-H⋯O inter-actions also occur.
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