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Updated: May 24, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Methyl (Z)-2-[(4-bromo-2-formyl-phen-oxy)meth-yl]-3-(4-methyl-phen-yl)acrylate
Abstract:
In the title compound, C(19)H(17)BrO(4), the dihedral angle between the two benzene rings is 82.9 (2)°. The mol-ecular structure is stabilized by an intra-molecular C-H⋯O hydrogen bond, which generates an S(7) ring motif. The crystal packing is stabilized by C-H⋯O hydrogen bonds, which generate two centrosymmetic ring systems with R(2) (2)(18) and R(2) (2)(14) graph-set motifs. The crystal packing is further stabilized by inter-molecular π-π inter-actions [centroid-centroid distance = 3.984 (2) Å].
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