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Generation of Murine Monoclonal Antibodies by Hybridoma Technology
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Generation of Murine Monoclonal Antibodies by Hybridoma Technology

Published on: January 2, 2017

Production of a natural antibody to the mouse polyoma virus is a multigenic trait

Erik Andrews, Palanivel Velupillai, Chang Kyoo Sung

    G3 (Bethesda, Md.)
    |March 14, 2012
    PubMed

    MA/MyJ mice express a natural antibody to the highly oncogenic polyoma virus. C57BR/cdJ mice lack this antibody but mount an adaptive T-cell response to the virus. Analysis of F2 progeny of a cross between these strains reveals a pattern of inheritance of expression of the natural antibody involving two genes in an epistatic relationship.

    Keywords:
    epistasismultigenic inheritancenatural antibodypolyoma virus

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