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Manual Restraint and Common Compound Administration Routes in Mice and Rats
Published on: September 26, 2012
Restraint of undomesticated animals
1Department of Physiology and Biochemistry, University College, Nairobi, Kenya, East Africa.
Journal of the American Veterinary Medical Association
|March 15, 2012
Summary
Chemical immobilization of 100 large African animals used compound M.99, a potent oripavine, for safe capture. Reversal agents nalorphine or M.285 effectively counteracted its effects.
Area of Science:
- Veterinary Medicine
- Wildlife Biology
- Pharmacology
Background:
- Chemical immobilization is crucial for wildlife research and management.
- Developing safe and effective immobilizing agents is an ongoing challenge.
Purpose of the Study:
- To evaluate the efficacy and safety of compound M.99 for immobilizing large African mammals.
- To establish protocols for administering and reversing the effects of M.99.
Main Methods:
- Compound M.99, a potent oripavine derivative, was administered via projectile syringe.
- Animals were typically co-administered a tranquilizer and scopolamine.
- Reversal was achieved using nalorphine or compound M.285.
Main Results:
- Approximately 100 large African animals across 17 species were successfully immobilized.
- Compound M.99 demonstrated high potency, approximately 1,000 times that of morphine.
- The small required dosage facilitated administration with a 2-ml projectile syringe.
Conclusions:
- Compound M.99 is a highly effective agent for chemical immobilization of diverse large African wildlife.
- The availability of specific reversal agents ensures animal safety and facilitates rapid recovery.
- This method offers a viable tool for wildlife capture and handling in research and conservation efforts.
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