[Effect of landiolol on bispectral index scores in patients undergoing lower abdominal surgery]

The aim of this study was to examine the effects of landiolol on bispectral index scores (BIS) during surgery.

Twenty patients undergoing total hysterectomy were allocated into two groups; 1) 10 patients not receiving landiolol (C group), 2) 10 patients receiving landiolol 125 microg x kg(-1) x min(-1) for one minute followed by 40 microg x kg(-1) x min(-1) (L group). They were anesthetized with sevoflurane (end-tidal concentration of 1.0%) combined with a continuous infusion of remifentanil at 0.25 microg x kg(-1) x min(-1). Mean arterial pressure (MAP), heart rate (HR) and BIS were recorded 4 times (immediately before the skin incision, 5 minutes after the skin incision, at the moment of uterine extraction and during retroperitoneal closure).

No significant differences were found in MAP and BIS between the groups at any time points, while HR in the L groups was lower than that in the C group throughout the study period.

This study suggests that landiolol has no effects on BIS in patients undergoing lower abdominal surgery during sevoflurane-remifentanil anesthesia.