Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antimicrobial prophylaxis for open heart operations.

L J Miedzinski1, J C Callaghan, E A Fanning

  • 1University of Alberta Hospitals, Edmonton, Canada.

The Annals of Thoracic Surgery
|November 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

When pooling fails: low-intensity <i>Angiostrongylus cantonensis</i> infections in <i>Theba pisana</i> result in false-negativity.

Journal of helminthology·2026
Same author

Efficacy of oral afoxolaner (NexGard®) against natural infestations with Heterodoxus spiniger (Phthiraptera: Boopiidae) in dogs under field conditions.

Veterinary parasitology, regional studies and reports·2025
Same author

Cutaneous Dirofilariasis Presenting as a Painless Inguinal Mass.

Irish medical journal·2025
Same author

Ecological drivers of helminth infection patterns in the Virunga Massif mountain gorilla population.

International journal for parasitology. Parasites and wildlife·2022
Same author

A multidisciplinary evaluation of suspected, non-confirmed cases of COVID-19 including chest CT, as compared to World Health Organization recommendations.

Clinical radiology·2021
Same author

The need for computed tomography imaging to differentiate the crowned dens syndrome from vertebral osteomyelitis.

Scandinavian journal of rheumatology·2020
Same journal

Does prior percutaneous coronary revascularization negatively affect the outcomes of subsequent coronary artery bypass grafting?

The Annals of thoracic surgery·2026
Same journal

Lymph Node Dissection and Chylothorax - Balancing Oncologic Benefit Against Morbidity.

The Annals of thoracic surgery·2026
Same journal

Preserved Antegrade Pulmonary Blood Flow in Bidirectional Glenn: Outcomes and Considerations for Staged Palliation.

The Annals of thoracic surgery·2026
Same journal

Domo Arigato, Mr. Roboto.

The Annals of thoracic surgery·2026
Same journal

Impact of High SUVmax on Recurrence by Resection Strategy in Stage IA Adenocarcinoma ≤2 cm.

The Annals of thoracic surgery·2026
Same journal

Preoperative Treatment for Stage II NSCLC Requires Multidimensional Consideration.

The Annals of thoracic surgery·2026
See all related articles

This study compared cephalothin and cefamandole for preventing infections after heart surgery. Cefamandole showed a trend toward fewer serious infections, particularly sternal wound infections, compared to cephalothin.

Area of Science:

  • Infectious Diseases
  • Cardiovascular Surgery
  • Pharmacology

Background:

  • Perioperative antibiotic prophylaxis is crucial in cardiac surgery to prevent surgical site infections.
  • Cephalothin and cefamandole are commonly used antibiotics for this purpose.
  • Emerging trends in pathogens necessitate ongoing evaluation of prophylactic strategies.

Purpose of the Study:

  • To compare the efficacy of cephalothin versus cefamandole in preventing postoperative infectious complications in adult patients undergoing cardiac surgery.
  • To identify the types and sources of major infections occurring post-cardiac surgery.
  • To assess the role of preoperative colonization in predicting postoperative infections.

Main Methods:

  • A prospective, randomized, comparative trial involving 450 adult patients undergoing coronary artery bypass or valve replacement surgery.

Related Experiment Videos

  • Patients received either cephalothin or cefamandole for perioperative prophylaxis.
  • Infectious complications were monitored during hospitalization and at 6 weeks and 6 months post-discharge.

    • Main Results:

    • Eleven major postoperative infections were reported: 5 sternal wound infections (3 bacteremic), 6 bacteremias, 1 prosthetic valve endocarditis, and 3 graft site infections.
    • Eight infections occurred in the cephalothin group and three in the cefamandole group.
    • All five sternal wound infections were in the cephalothin group; gram-negative aerobes and Staphylococcus aureus were common pathogens.

    Conclusions:

    • While not statistically significant, cefamandole demonstrated a trend towards reduced major postoperative infections compared to cephalothin.
    • Gram-negative aerobes are increasingly significant pathogens in this surgical setting.
    • Preoperative staphylococcal colonization did not predict postoperative staphylococcal infections.