Related Experiment Video
Updated: May 24, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
Published on: May 22, 2019
[A psychotropic drug treatment of psychiatric symptoms after stroke]
1Department of Neuropsychiatry, Nippon Medical School Chiba Hokuso Hospital.
Abstract:
Psychiatric syndromes are common in the patients with cerebrovascular disease. Poststroke depression (PSD) is a most frequent complication of after cerebrovascular disease. Depression affects 20-50% of patients within a year after stroke. PSD has a negative impact on functional recovery. Poststroke anxiety disorder, apathy and pathological laughing and crying are also frequent and under-detected symptoms. In this chapter, we described an outline mainly on treatment of PSD among these symptoms, in paticular, about antidepressant medications. There is an association between depression and atherosclerosis. Several trials have shown evidence that antidepressants may prevent depressive symptoms after stroke. The concept of "vascular depression" will suggest that the establishment of a new treatment strategy is demanded in future.
Related Concept Videos
Psychosis: Goals of Pharmacotherapy
Drug Therapy
Antianxiety Medications
Psychosis and Antipsychotic Drugs: Overview
Antidepressant Drugs: MAOIs and Other Agents
Alzheimer's Disease: Treatment
Antipsychotic Drugs: Therapeutic Uses and Side Effects
Despite these side effects, antipsychotics are used therapeutically for various purposes, including managing schizophrenia, preventing nausea and vomiting, curbing...