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Updated: May 24, 2026
07:04
Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans
Published on: August 15, 2020
[Neurodegenerative diseases]
Masashi Takanashi1, Nobutaka Hattori
1Department of Neurology, Juntendo University School of Medicine.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|March 15, 2012
Summary
Neurodegenerative diseases involve neurotransmitter changes. For psychosis in Parkinson's disease (PD) and dementia with Lewy bodies (DLB), atypical antipsychotics like quetiapine are recommended to avoid worsening symptoms.
Area of Science:
- Neuroscience
- Neurology
- Pharmacology
Context:
- Neurodegenerative diseases feature pathological changes, neuronal loss, and gliosis.
- Central nervous system neurotransmitter alterations are key in these conditions.
- Alzheimer's disease involves cholinergic neuron depletion, while Parkinson's disease (PD) primarily affects dopaminergic neurons.
Purpose:
- To review the impact of antipsychotic drugs on neurodegenerative diseases.
- To recommend appropriate treatments for psychosis in PD and dementia with Lewy bodies (DLB).
Summary:
- Antipsychotic medications can exacerbate parkinsonism and neuroleptic malignant syndrome in PD and DLB patients.
- Atypical antipsychotics, particularly quetiapine, are suggested as a safer alternative for managing psychosis in these patient groups.
- This recommendation aims to mitigate adverse effects associated with traditional antipsychotics.
Impact:
- Provides guidance for clinicians treating psychosis in patients with PD and DLB.
- Highlights the importance of selecting specific antipsychotic agents to improve patient safety and outcomes.
- Contributes to the understanding of pharmacotherapy in complex neurological conditions.
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