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Updated: May 24, 2026

Demonstrating a Multi-drug Resistant Mycobacterium tuberculosis Amplification Microarray
Published on: April 25, 2014
[Molecular epidemiology of multidrug-resistant organisms]
1Department of Infection Prevention and Control, Yokohama City University Hospital.
Abstract:
Recent advance in molecular epidemiology of multidrug-resistant organisms (MDROs) was described. Most of MDROs are spreading over the world in a short period, monitoring of certain epidemic strains of MDROs is very important. Since Cantor et al. developed pulsed-field gel electrophoresis (PFGE) in 1984, genotyping tools became major tools for laboratory based-epidemiologic analysis. Recent advance was developed by two major technologies. One is multilocus sequence typing (MLST) and the other one is matrix assisted laser desorption ionization-time of flight-mass spectrometry (MALDI-TOF-MS). MALDI-TOF-MS technology is still under developing, but near future it will become major tools for MDROs molecular epidemiology.
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