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Related Experiment Video

Updated: May 24, 2026

Characterizing Multidrug Efflux Systems in Acinetobacter baumannii Using an Efflux-Deficient Bacterial Strain and a Single-Copy Gene Expression System

Characterizing Multidrug Efflux Systems in Acinetobacter baumannii Using an Efflux-Deficient Bacterial Strain and a Single-Copy Gene Expression System

Published on: January 5, 2024

[Acinetobacter spp].

Naohisa Matsunaga¹

¹Department of Infection Control and Prevention, Teikyo University Hospital.

Nihon Rinsho. Japanese Journal of Clinical Medicine

|March 15, 2012

Summary

Multidrug-resistant Acinetobacter species (MDRA) are a growing concern, especially in healthcare settings. Controlling MDRA requires strict hygiene, environmental disinfection, and careful antibiotic use due to limited treatment options.

Area of Science:

Microbiology
Infectious Diseases
Antimicrobial Resistance

Context:

Acinetobacter species are ubiquitous, gram-negative bacteria known for environmental persistence.
These bacteria are frequently implicated in nosocomial infections, with pneumonia being common.
Multidrug-resistant Acinetobacter species (MDRA) pose a significant challenge in healthcare.

Purpose:

To define multidrug-resistant Acinetobacter species (MDRA) based on specific antimicrobial resistance criteria in Japan.
To highlight the limited treatment options for MDRA infections in Japan.
To emphasize key strategies for controlling MDRA transmission and infections.

Summary:

MDRA are defined by specific minimum inhibitory concentrations (MICs) for imipenem, amikacin, and ciprofloxacin in Japan.

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Characterizing Multidrug Efflux Systems in Acinetobacter baumannii Using an Efflux-Deficient Bacterial Strain and a Single-Copy Gene Expression System

Characterizing Multidrug Efflux Systems in Acinetobacter baumannii Using an Efflux-Deficient Bacterial Strain and a Single-Copy Gene Expression System

Published on: January 5, 2024

Quantification, Viability Assessment, and Visualization Strategies for Acinetobacter Biofilms

Quantification, Viability Assessment, and Visualization Strategies for Acinetobacter Biofilms

Published on: August 4, 2023

The lack of approval for certain antibiotics like colistin, polymyxin B, and tigecycline restricts treatment choices.

Effective MDRA control hinges on stringent adherence to infection control precautions, environmental hygiene, and judicious antibiotic stewardship.

Impact:

Provides clear definitions and surveillance criteria for MDRA in Japan.
Underscores the urgent need for novel therapeutic strategies and improved infection control measures.
Informs public health policy and clinical practice for managing challenging gram-negative bacterial infections.