Related Experiment Video
Updated: May 24, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
[The managements of nosocomial outbreaks of multi-drug resistant bacteria]
1Division of Infection Control and Prevention, Osaka University Hospital.
Abstract:
Hospital outbreaks of multi-drug resistant bacteria have been reported in a number of contexts, particularly in areas where seriously ill patients are treated, for example in intensive care units sometimes with spread to other wards. When the serious outbreak occurs, the hospital had better to make official announcement and receive third-party assessment. The local network for consultation is also recommended by Japanese Ministry of Health, Labor and Welfare. The outbreaks of multi-drug resistant pathogens are easily recognized, but surrounding the outbreaks, numerous numbers of drug sensitive bacterial outbreaks must occur in obscurity. Then the concept of "never events" should be spread for prevent nosocomial infections, also in Japan.
Insights
Hospital outbreaks of multi-drug resistant bacteria are a serious concern, especially in intensive care units. Prompt official announcements, third-party assessments, and consultation networks are recommended to manage these events and prevent healthcare-associated infections.
Area of Science:
- Infectious Diseases
- Microbiology
- Public Health
Context:
- Hospital outbreaks of multi-drug resistant bacteria (MDRB) are frequently reported, particularly in intensive care units (ICUs) and can spread to other hospital wards.
- These outbreaks pose significant challenges to patient safety and healthcare systems.
- The Japanese Ministry of Health, Labor and Welfare recommends official announcements, third-party assessments, and local consultation networks for serious outbreaks.
Purpose:
- To highlight the challenges posed by hospital outbreaks of multi-drug resistant bacteria.
- To emphasize the need for established protocols in managing serious outbreaks.
- To introduce the concept of 'never events' for preventing nosocomial infections.
Summary:
- Multi-drug resistant bacterial outbreaks are often recognized, but drug-sensitive bacterial outbreaks may occur unnoticed.
- Effective management strategies include official announcements, external assessments, and collaborative consultation networks.
- Preventing healthcare-associated infections requires a comprehensive approach, including awareness of 'never events'.
Impact:
- Improved patient safety through timely and effective outbreak management.
- Reduced transmission of both resistant and sensitive bacteria within healthcare settings.
- Enhanced national strategies for infection prevention and control in hospitals.
Related Concept Videos
Clinical Significance of Antibiotic Resistance
Mechanism of Antibiotic Resistance in MRSA
Development of Antibiotic Resistance
Acute Pyelonephritis II: Diagnostic Studies and Management
Healthcare Associated Infections II: Preventive Measures
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
Infection
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...

