Related Experiment Video
Updated: May 24, 2026
06:39
Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings
Published on: June 13, 2025
[Circadian rhythm abnormality and hypertension]
1Department of System Biology, Graduate School of Pharmaceutical Sciences, Kyoto University.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|March 15, 2012
Summary
Disrupted circadian rhythms disrupt body systems, leading to hypertension. Mice lacking clock genes Cry1 and Cry2 exhibit salt-sensitive hypertension due to high aldosterone synthesis.
Area of Science:
- Chronobiology
- Endocrinology
- Cardiovascular Physiology
Context:
- Modern lifestyles disrupt natural circadian rhythms, impacting physiological and metabolic health.
- Circadian rhythms, governed by cellular clocks, regulate numerous bodily functions and behaviors.
- Compromised circadian function poses a significant public health concern.
Purpose:
- To investigate the link between circadian clock gene disruption and hypertension.
- To identify the molecular mechanisms underlying circadian rhythm-associated salt-sensitive hypertension.
Summary:
- Arrhythmic mice lacking the clock genes Cry1 and Cry2 (Cry-null mice) develop salt-sensitive hypertension.
- This hypertension is associated with abnormally high synthesis of the mineralocorticoid aldosterone in the adrenal gland's zona glomerulosa.
- A clock-controlled enzyme, 3beta-hydroxyl-steroid dehydrogenase, is implicated as a potential cause of this hypertension.
Impact:
- Provides insights into the molecular basis of circadian rhythm disruption-induced hypertension.
- Highlights the role of aldosterone synthesis in the development of salt-sensitive hypertension.
- Suggests potential therapeutic targets for managing hypertension related to circadian dysfunction.
Related Concept Videos
02:19Circadian Rhythms and Gene Regulation
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
02:19Circadian Rhythms and Gene Regulation
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
01:15Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
01:30Alterations in Blood Pressure
Alterations in blood pressure, such as hypertension (high blood pressure) and hypotension (low blood pressure), significantly affect human health. Understanding these conditions' classifications, causes, and symptoms is essential for effective management and treatment.
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart beats)...
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart beats)...
01:30Hypertension III: Clinical Manifestations and Diagnostic Studies
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
01:29Hypertension II: Pathophysiology
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...