Related Experiment Video

Updated: May 24, 2026

Experimental Generation of Carcinoma-Associated Fibroblasts (CAFs) from Human Mammary Fibroblasts
15:43

Experimental Generation of Carcinoma-Associated Fibroblasts (CAFs) from Human Mammary Fibroblasts

Published on: October 25, 2011

Myofibroblastoma of breast in a male infant

Tutku Soyer1, Sebnem Ayva, Mine F Senyucel

  • 1Kirikkale University, Medical faculty, Pediatric Surgery, Kirikkale, Turkey. soyer.tutku@gmail.com

Fetal and Pediatric Pathology
|March 15, 2012
PubMed

Insights

A rare myofibroblastoma breast mass was diagnosed in a 10-month-old infant. This case highlights the clinical features and treatment of pediatric breast myofibroblastomas, a tumor not previously reported in infants.

Area of Science:

  • Pediatric Oncology
  • Breast Pathology

Background:

  • Breast masses in infants are uncommon, with premature thelarche due to estrogen being the most frequent cause.
  • Myofibroblastomas are rare stromal tumors typically found in older males, linked to androgen receptors.

Observation:

  • A 10-month-old male infant presented with a left breast mass.
  • The mass was diagnosed as a myofibroblastoma through histopathological examination.

Findings:

  • This represents the first reported case of a myofibroblastoma in an infant.
  • The study aims to detail the clinical presentation and therapeutic strategies for pediatric breast myofibroblastomas.

Implications:

  • This case expands the known age range for myofibroblastoma occurrence.
  • Understanding the clinical behavior and treatment of pediatric breast myofibroblastomas is crucial for accurate diagnosis and management.

More Related Videos

Murine Dermal Fibroblast Isolation by FACS06:04

Murine Dermal Fibroblast Isolation by FACS

Published on: January 7, 2016

Related Concept Videos

Introduction to Fibroblasts01:09

Introduction to Fibroblasts

Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
Formation of Muscle Fibers from Myoblasts01:13

Formation of Muscle Fibers from Myoblasts

De novo myogenesis, or the formation of muscle fibers, begins during the early embryonic stages. The skeletal muscle is formed from somites– blocks of embryonic cell layers. The somites are further divided into dermatomes, myotomes, sclerotomes, and syndetomes. Among these, the myotomes give rise to muscle fibers.
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription factors...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...