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Synthesizing the tetracyclic core of nanolobatolide
Le Chang1, Hao Jiang, Junkai Fu
1Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China.
The Journal of Organic Chemistry
|March 15, 2012
Abstract:
A concise synthetic pathway that enables the stereoselective construction of the tetracyclic core of nanolobatolide has been developed by applying a tandem ring-closing metathesis (RCM) reaction of dienynes, a Eu(fod)(3)-catalyzed intermolecular Diels-Alder reaction, and a biomimetic epoxide opening reaction as key steps.

