Jove
Visualize
Contact Us

Related Concept Videos

Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide generation. 
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel Disease...
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2 (COX-2),...
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab (Humira),...
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The impact of EU public procurement regulations on tenders in Spain: a study with adalimumab.

Frontiers in pharmacology·2024
Same author

Effects of different obesogenic diets on joint integrity, inflammation and intermediate monocyte levels in a rat groove model of osteoarthritis.

Frontiers in physiology·2023
Same author

Extracellular Vesicles From the Helminth <i>Fasciola hepatica</i> Prevent DSS-Induced Acute Ulcerative Colitis in a T-Lymphocyte Independent Mode.

Frontiers in microbiology·2018
Same author

Shikonin promotes intestinal wound healing in vitro via induction of TGF-β release in IEC-18 cells.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2013
Same author

Traditional chinese medicine remedy to jury: the pharmacological basis for the use of shikonin as an anticancer therapy.

Current medicinal chemistry·2013
Same author

Cocoa polyphenols and their potential benefits for human health.

Oxidative medicine and cellular longevity·2012
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Anti-inflammatory agents from plants: progress and potential.

M C Recio1, I Andujar, J L Rios

  • 1Department of Pharmacology, Faculty of Pharmacy, University of Valencia, Spain. maria.c.recio@uv.es

Current Medicinal Chemistry
|March 15, 2012
PubMed
Summary

This review explores plant-derived compounds like curcumin and resveratrol for treating chronic inflammatory diseases, such as rheumatoid arthritis (RA) and inflammatory bowel disease (IBD). These natural therapies offer promising, well-tolerated anti-inflammatory effects.

Related Experiment Videos

Area of Science:

  • Pharmacology
  • Natural Product Chemistry
  • Immunology

Background:

  • Chronic inflammatory diseases like rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) represent a significant global health burden.
  • Traditional medicine, particularly plant-derived therapies, is increasingly recognized for its potential in managing these conditions.
  • Identifying safe and effective anti-inflammatory agents from natural sources is crucial for developing novel therapeutic strategies.

Purpose of the Study:

  • To review recent clinical and preclinical advancements in the use of plant extracts and compounds for treating RA and IBD.
  • To highlight key anti-inflammatory agents derived from medicinal plants, including green tea polyphenols, curcumin, resveratrol, boswellic acid, and cucurbitacins.
  • To assess the therapeutic potential and mechanisms of action of these natural compounds in chronic inflammatory diseases.

Main Methods:

  • Systematic literature review of clinical trials and experimental studies.
  • Analysis of data on plant extracts and isolated compounds with anti-inflammatory properties.
  • Focus on studies investigating efficacy in animal models of rheumatoid arthritis and inflammatory bowel disease.

Main Results:

  • Several plant-derived compounds, including curcumin, resveratrol, and boswellic acid, demonstrate significant anti-inflammatory effects in preclinical models of RA and IBD.
  • Green tea polyphenols show promise in modulating inflammatory pathways relevant to these chronic conditions.
  • Clinical data, though emerging, supports the potential of these natural agents as well-tolerated therapeutic options.

Conclusions:

  • Plant-derived compounds offer a promising avenue for the development of novel, homeostatic, and modulatory treatments for chronic inflammatory diseases.
  • Further clinical investigation is warranted to fully establish the efficacy and safety of these natural therapies for rheumatoid arthritis and inflammatory bowel disease.
  • Medicinal plants continue to be a valuable resource for discovering potent anti-inflammatory agents with potential pharmaceutical applications.