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Related Experiment Videos

Metoclopramide on rat phrenic hemidiaphragm.

J R Vedasiromoni1, K K Maitra, B K Chakravarty

  • 1Division of Pharmacology and Experimental Therapeutics, Indian Institute of Chemical Biology, Calcutta.

Archives Internationales De Pharmacodynamie Et De Therapie
|May 1, 1990
PubMed
Summary

Metoclopramide inhibits rat diaphragm muscle contractions, with greater effects on nerve-stimulated responses. This study suggests metoclopramide acts as a calcium antagonist in skeletal muscle.

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Area of Science:

  • Pharmacology
  • Neuroscience
  • Muscle Physiology

Background:

  • Metoclopramide is a widely used antiemetic drug.
  • Its effects on skeletal muscle and neurotransmission are not fully understood.
  • Investigating these effects can reveal novel therapeutic applications or side effects.

Purpose of the Study:

  • To investigate the effects of metoclopramide on skeletal muscle contractility.
  • To explore the impact of metoclopramide on neuromuscular transmission.
  • To determine the mechanism underlying metoclopramide's action on rat diaphragm muscle.

Main Methods:

  • Experiments were conducted on innervated and denervated rat diaphragm preparations.
  • Muscle contractions were stimulated directly and indirectly.

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  • The effects of metoclopramide were assessed in various physiological solutions, including calcium-free and magnesium-rich environments.
  • Responses to potassium chloride, acetylcholine, and caffeine were measured.

    • Main Results:

    • Metoclopramide inhibited twitch contractions in both directly and indirectly stimulated rat diaphragm.
    • Inhibition was more pronounced in indirectly stimulated preparations.
    • Magnesium chloride enhanced metoclopramide's inhibitory effect on indirect twitches.
    • Metoclopramide also inhibited denervated diaphragm contractures induced by potassium chloride and acetylcholine.
    • Caffeine-induced contractures were inhibited by metoclopramide in a dose-dependent manner in calcium-free solution.

    Conclusions:

    • Metoclopramide exhibits inhibitory effects on rat skeletal muscle contractility and neurotransmission.
    • The drug's action is more significant on nerve-mediated contractions.
    • Evidence suggests metoclopramide possesses calcium antagonistic properties in the rat diaphragm.
    • These findings contribute to understanding metoclopramide's pharmacological profile beyond its antiemetic effects.