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Systemic therapy in metastatic colorectal cancer
1Division of Hematology/Oncology, Medical College of Wisconsin, Milwaukee.
Archives of Internal Medicine
|November 1, 1990
Summary
Fluorouracil chemotherapy for metastatic colorectal cancer shows improved response rates with continuous infusion and folinic acid modulation. However, survival benefits are less significant, and costs and toxicity may increase.
Area of Science:
- Oncology
- Medical Chemistry
Background:
- Fluorouracil has been a cornerstone in metastatic colorectal cancer treatment for over three decades.
- Initial combination chemotherapy regimens did not yield significant improvements.