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The Retinoblastoma Gene

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Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

The Retinoblastoma Gene

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Related Experiment Video

Updated: May 24, 2026

Reconstruct Human Retinoblastoma In Vitro

Reconstruct Human Retinoblastoma In Vitro

Published on: October 11, 2022

Retinoblastoma.

Helen Dimaras¹, Kahaki Kimani, Elizabeth A O Dimba

¹Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada.

Lancet (London, England)

|March 15, 2012

Summary

This summary is machine-generated.

Retinoblastoma, an aggressive childhood eye cancer, has high mortality in low-income countries. Global digital communication and genetic technologies offer opportunities to improve care and reduce deaths.

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Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice

Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice

Published on: August 4, 2011

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Last Updated: May 24, 2026

Reconstruct Human Retinoblastoma In Vitro

Reconstruct Human Retinoblastoma In Vitro

Published on: October 11, 2022

Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice

Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice

Published on: August 4, 2011

Area of Science:

Oncology
Ophthalmology
Genetics

Background:

Retinoblastoma is a severe infant and childhood eye cancer with variable survival rates based on presentation severity.
Despite understanding its genetic origins, mortality remains high (around 70%) in low and middle-income countries.
Progress is hindered by low public/medical awareness and lack of clinical trials for innovative treatments.

Purpose of the Study:

To highlight the global disparities in retinoblastoma outcomes.
To explore the potential of digital communication and advanced technologies in improving care standards.
To advocate for enhanced awareness, genetic testing, and collaborative research to reduce mortality.

Main Methods:

Review of current challenges in retinoblastoma management.
Identification of opportunities presented by global digital communication.
Emphasis on leveraging genome-level technologies for genetic testing.
Promotion of best-practice guidelines, data sharing, and clinical trials.

Main Results:

An estimated 9000 new cases annually face high mortality, particularly in resource-limited settings.
Digital communication offers a platform to optimize care standards globally.
Parent advocacy is crucial for raising awareness about early signs like leucocoria.
Genomic technologies can facilitate widespread genetic testing for affected families.

Conclusions:

Improving retinoblastoma survival requires a multi-faceted approach including enhanced awareness and accessible genetic testing.
Global collaboration through digital platforms and rigorous research is essential to reduce mortality.
Prioritizing the holistic wellbeing of children through survivor and family involvement is paramount.