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Increased urinary podocytes following indomethacin suggests drug-induced glomerular injury

Alison L Kent1, Linda Brown, Margaret Broom

  • 1Department of Neonatology, Canberra Hospital, PO Box 11, Woden, 2606, ACT, Australia. alison.kent@act.gov.au

Pediatric Nephrology (Berlin, Germany)
|March 15, 2012
PubMed

Insights

Preterm infants exposed to indomethacin showed increased urinary podocytes and albumin, indicating glomerular injury. Further research is needed to understand long-term renal effects in these vulnerable infants.

Area of Science:

  • Neonatal research
  • Pediatric nephrology
  • Renal development

Background:

  • Glomerulogenesis continues post-birth in preterm infants, making them susceptible to renal insults.
  • Urinary podocytes serve as a biomarker for glomerular injury.
  • Medications like gentamicin and indomethacin may impact developing kidneys.

Purpose of the Study:

  • To investigate podocyte excretion in preterm and term infants.
  • To determine if gentamicin and indomethacin exposure increases urinary podocyte excretion.

Main Methods:

  • Urine samples collected daily from preterm infants (<33 weeks gestation) on gentamicin or indomethacin.
  • Urine samples collected for 3 days from preterm and term control infants.
  • Quantification of urinary podocytes and casts compared between groups.

Main Results:

  • Forty-two neonates participated.
  • Both preterm and term controls excreted minimal podocytes (<2).
  • Preterm infants receiving indomethacin showed significantly higher podocyte and albumin excretion (p=0.02).

Conclusions:

  • Elevated urinary podocytes and albumin in preterm infants on indomethacin suggest glomerular injury.
  • The long-term consequences of this early glomerular injury on renal development and adult function remain unknown.
Abstract

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